Fibrinogen concentrate use during major obstetric haemorrhage
نویسندگان
چکیده
منابع مشابه
The Efficacy of Fibrinogen Concentrate Compared to Cryoprecipitate in Major Obstetric Haemorrhage – an Observational Study. Authors
Background Fibrinogen replacement is critical in major obstetric haemorrhage (MOH).Purified, pasteurized fibrinogen concentrate appears to have benefitover cryoprecipitate in ease of administration and safety but is unlicensed in pregnancy. In July 2009 the Irish Blood Transfusion Service replaced cryoprecipitate with fibrinogen.
متن کاملThe Clinical Efficacy of Fibrinogen Concentrate in Massive Obstetric Haemorrhage with Hypofibrinogenaemia
Massive obstetric haemorrhage remains a major cause of maternal death attributable to hypofibrinogenaemia. Transfusion of large volumes of fresh frozen plasma (FFP) is required to normalise fibrinogen levels. We compared the efficacy of FFP (F group) with that of FFP plus fibrinogen concentrate (F + F group) in massive obstetric haemorrhage. In this retrospective study, we compared the medical ...
متن کاملChallenges of major obstetric haemorrhage.
Every minute of every day, a woman dies in pregnancy or childbirth. The biggest killer is obstetric haemorrhage, the successful treatment of which is a challenge for both the developed and developing worlds. The presence of an attendant at every birth and access to emergency obstetric care are key to reducing maternal morbidity and mortality in the developing world while resource-rich countries...
متن کاملStrategies to manage major obstetric haemorrhage.
PURPOSE OF REVIEW Haemorrhage remains a cause of significant maternal morbidity and mortality. This review summarizes the prevention, management and treatment of obstetric haemorrhage and highlights recent advances and developments. RECENT FINDINGS Postpartum haemorrhage is the most common cause of major obstetric haemorrhage and is usually due to uterine atony. Pharmacological treatment has ...
متن کاملViscoelastometric-guided early fibrinogen concentrate replacement during postpartum haemorrhage: OBS2, a double-blind randomized controlled trial.
Background Postpartum haemorrhage (PPH) can be exacerbated by haemostatic failure. We hypothesized that early fibrinogen replacement, guided by viscoelastometric testing, reduces blood product usage and bleed size. Methods Women with PPH 1000-1500 ml were enrolled. If Fibtem A5 was ≤15 mm and bleeding continued, subjects were randomized to fibrinogen concentrate or placebo. The primary outcom...
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ژورنال
عنوان ژورنال: Anaesthesia
سال: 2010
ISSN: 0003-2409
DOI: 10.1111/j.1365-2044.2010.06548.x